Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stassi, D.; Donadio, S.; Staver, M.J.; Katz, L.
    Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis (1993), J. Bacteriol., 175, 182-189.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.154
-
 Saccharopolyspora erythraea

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.13.154 43759
-
 x * 43759, calculated from sequence Saccharopolyspora erythraea

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.154 Saccharopolyspora erythraea P48635
-
-

Subunits

EC Number Subunits Comment Organism
1.14.13.154 ? x * 43759, calculated from sequence Saccharopolyspora erythraea

Synonyms

EC Number Synonyms Comment Organism
1.14.13.154 EryK
-
 Saccharopolyspora erythraea
1.14.13.154 erythromycin C-12 hydroxylase
-
 Saccharopolyspora erythraea

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.154 cytochrome P-450 a heme-thiolate protein (P-450) Saccharopolyspora erythraea

General Information

EC Number General Information Comment Organism
1.14.13.154 malfunction an Saccharopolyspora erythraea strain disrupted in eryK no longer produces erythromycin A but accumulates the B and D forms of the antibiotic Saccharopolyspora erythraea
1.14.13.154 physiological function the enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis Saccharopolyspora erythraea